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Enzyme-Active Retinol Serum


  • Rapidly smoothes skin texture (usually within 7 days)
  • Clarifies complexion & controls oil (in 2-3 weeks)
  • Fills in deep lines or wrinkles (within a single bottle, guaranteed)
  • Lab-made batch, ready to ship

This award-winning serum captures the most gentle and effective form retinol on Earth (retinal)––estimated by dermatologists to be 20x more effective than regular retinol. This elusive ingredient is captured using Protocol’s patented oxygen-free bottling technology, designed by the Protocol Lab Team in collaboration with aerospace engineers.

Most clients see improvements within 10 days.

Formulation and active ingredient found to be more effective at reversing wrinkles and dark spots than a $5,000 glycolic acid chemical peel applied in a clinical setting.
C. Rouvrais. Journal of Cosmetic Dermatology 2018 Dec;17(6):1136-1143

Key Active:0.1% retinal, the enzyme-calibrated form of retinol. (i.e., naturally-occuring retinaldehyde)

All products are vegan, cruelty free and 100% recyclable through our Emptiez Recycling Program.



Aloe Barbadensis Leaf Juice, Water, Niacinamide, Cyclodextrin, Caprylic/Capric Triglyceride, Gluconolactone, Carnitine (L), Glycerin, Polysorbate 20, Enzyme-Active Retinol/Retinal/Retinaldehyde, Phenylethyl Resorcinol, Bisabolol (L-alpha), Tocopheryl Acetate (D-alpha), Lonicera Japonica Flower Extract, Lonicera Caprifolium Flower Extract, Sodium Lactate, Lecithin, Ethanol, Pentylene Glycol, Maltodextrin, Xanthan Gum, Sodium Benzoate


Apply one pump at night after cleansing or rinsing with water while skin is still damp. Beginning users should wait a few minutes or until dry before following up with evening moisturizer. Advanced users can wait up to 30 minutes before applying moisturizer to maximize potency. This product is compatible with other toners or actives, however, as a general practice our lab team recommends a simple cleanser, active, moisturizer routine for all skin types. Our clients often find that this serum allows them to remove several steps from their routine with better results.




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